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香港,中国 - Media OutReach - 2019年4月19日 - 在香港,多发性骨髓瘤发病年龄多介于60至70岁之间,常见病征包括骨痛、贫血、血钙升高及肾功能受损,由于症状不明显,容易忽略,以致耽误治疗。临床上不少患者等到骨痛难捱而求诊,才发现患上了多发性骨髓瘤,所以属高危年龄的人士,如果骨痛持续于休息或睡眠的时候出现,甚至半夜痛醒,就应及早求医作详细检查。

夜半骨痛影响睡眠 小心罹患多发性骨髓瘤

血液及血液肿瘤科陈敏航医生

 

多发性骨髓瘤无法根治,以往整体生存期只有2至3年,缓解率也欠佳,近年新型药物面世提升了生存率,不少病例可延长达10年的生命,并同时可缓解症状以保持生活质量。目前新一代的治疗方案,是确诊后先进行诱导治疗,当中搭配2至3种药物,包括类固醇、免疫调节剂、以及较新型的靶向药物如蛋白酶体抑制剂;当病情逐渐稳定后,65岁以下较年轻患者可安排进行自体骨髓移植手术作为巩固治疗,并随后接受约2年的维持治疗。如果患者超过65岁不宜做自体骨髓移植,则可诱导治疗后接受维持治疗。

 

新型蛋白酶体抑制剂有皮下注射、静脉注射及口服等剂型,效果、起效速度和副作用各不相同,较新的蛋白酶体抑制剂卡非佐米,属起效快,副作用少的药物,此药有两种不同的注射剂量,以适合不同体重的患者,对患者而言除了较方便,也不会造成药物浪费,某种程度上可减轻医药开支。

 

曾有一位已年近八十的婆婆,于3年前因跌断大腿骨而求医,继而经详细检查后,确诊患有多发性骨髓瘤。当时只能接受传统药物治疗,却于1年后病情恶化,出现严重骨痛和不明原因发烧,需长期住院医治。近年婆婆因希望与伴侣在一起而转至私家医院,并接受较积极的药物治疗。经注射蛋白酶体抑制剂卡非佐米后,患者的病征得以缓解,病情有显著的改善,离世前的生活质量一直得以保持。最令人感动和鼓舞的是婆婆在有限的时间内能做到自己想做的事情。

 

资料来源:

健康研究所

Source http://www.media-outreach.com/release.php/View/8553#Contact

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